CORTAMETHASONE

CORTAMETHASONE  It´s a Vetoquinol Dexa, 1mg / ml, excellent product for racing events, acts on many systems of the animal and the result is a remarkable increase in the performance

Target species: Equine, Camel, cattle, goats, pigs, dogs and cats.

Indications for use, specifying the target species

In horses, cattle, goats, pigs, dogs and cats:
– Treatment of inflammatory, allergic or shock conditions.

In cattle and goats:
– Treatment of primary ketosis (acetoneemia, pregnancy toxemia).
– Induction of parturition.

In the equine:
– Treatment of osteoarticular inflammatory states.

Cons-indications
Don´t use in animals suffering from diabetes mellitus, hyperadrenocorticism, renal insufficiency and heart failure or suffering from peptic ulcers.
Don´t use in animals with infectious disease, unless appropriate anti-infectious therapy is administered at the same time.

Special warnings for each target species

In horses and Camel, dexamethasone should only be used at the beginning of the disease during laminitis.
See section “Use in the event of pregnancy, lactation or laying”.

Special precautions for use CORTAMETHASONE

I) Special precautions for use in animals

Administration of corticosteroids at the end of pregnancy may result in premature delivery or abortion in ruminants.
Except in the indications of acetonaemia and induction of parturition, the function of corticosteroids is to improve rather than cure. Therefore, it´s advisable to diagnose and treat the underlying disease. When used to treat shock, intravenous fluids should be administered to maintain circulation; An acid-base assessment must be carried out.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

In case of accidental self-injection, seek medical advice immediately and show the package leaflet.
Persons with known hypersensitivity to the active substance or to any of the excipients should avoid contact with the veterinary medicinal product.
Pregnant women should not handle this veterinary drug.

Undesirable effects (frequency and severity)

In prolonged use, corticosteroids such as dexamethasone may cause iatrogenic hypercorticism, polyuropolydipsia (PUPD), immunosuppression, bulimia and redistribution of the body’s lipid reserves.
The use of corticosteroids in lactating cattle and goats may lead to a temporary decline in milk production.
Induction of parturition with corticosteroids may be associated with reduced progeny viability and increased incidence of placental retention.

Use in pregnancy, lactation or laying CORTAMETHASONE

Studies in laboratory animals have demonstrated embryotoxic effects.
The use of corticosteroids in pregnant females is not recommended except in ruminants to induce parturition during the last third of gestation.

Drug Interactions and Other Forms of Interaction

Acts on several systems of the animal and the result is a remarkable increase in the performance

Because corticosteroids can reduce the immune response to vaccination, dexamethasone should not be given at the same time as vaccines.
Concomitant use of non-steroidal anti-inflammatory drugs may increase the risk of ulceration of the gastrointestinal tract.

Dosage and route of administration all species CORTAMETHASONE

Intravenous or intramuscular use.
Equine, Camel, cattle, goats, pigs 0.04 to 0.10 mg / kg (4 to 10 ml / 100 kg)
Dogs, cats 0.05 to 0.10 mg / kg (0.5 to 1 ml / 10 kg)

Dosification & Administration for Race :
For professional application not detected, read the article about dexa for race

For safe application not detected pre-race: 5 ml for 5 days, suspend 2 days before the race

Overdose (symptoms, emergency management, antidotes), if necessary

High doses of corticosteroids may cause somnolence and lethargy in equines.

Waiting time

Meat and offal: 6 days.
Milk: 3 days.

Pharmacological Properties

Pharmacotherapeutic group: corticosteroids for systemic use, glucocorticoid.
ATC-vet code: QH02AB02.

Pharmacodynamic Properties

Dexamethasone is a potent synthetic with low mineralocorticoid activity. Dexamethasone has ten to twenty times the anti-inflammatory activity of prednisolone at an equivalent molar dose. Corticosteroids may decrease the immune response. Indeed, they inhibit capillary dilation, leukocyte migration and phagocytosis. Glucocorticoids have an effect on metabolism by increasing gluconeogenesis. Dexamethasone induces parturition in ruminants if the fetus is alive.

Pharmacokinetic properties

After administration of the product intramuscularly, dexamethasone is absorbed rapidly, resulting in a rapid and short-acting response. T max in cattle, goats, horses, pigs, dogs and cats is reached within 30 minutes after intramuscular administration. The T½ (half-life time) varies depending on the species between 5 and 20 hours. The bioavailability after intramuscular administration is approximately 100%.

Pharmaceutical Information

List of excipients:

Benzyl alcohol (E1519)
dimethylacetamide
Propylene glycol
Water for injections

Major Incompatibilities: Not known.

The duration of the conversation:

3 years.
After opening: 28 days.

Special precautions for storage

Any.

Nature and composition of primary packaging

Glass bottle
Special precautions to be taken when disposing of unused veterinary medicinal products or waste derived from the use of such medicinal products

Empty packagings and any residues of product should be disposed of in accordance with current practices regulated by the waste